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The group of Patrick Koelsch focuses on the in situ and in vitro characterization of biofunctional interfaces using in particular laser-based spectroscopy. Experimental techniques include broadband sum-frequency-generation (SFG) and second-harmonic-generation (SHG) spectroscopy as well as UV-Vis, Raman, FTIR, and ellipsometry. Our research areas cover thin films such as DNA and polymeric layers, biofilms, cell adhesion and extracellular matrix, ion-specific effects and spectro-electrochemistry, membrane proteins, and photocatalysis.
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- Diesner, M.-O., Welle, A., Kazanci, M., Kaiser, P., Spatz, J., and P. Koelsch, In vitro observation of dynamic odering processes in the extracellular matrix of adherent cells, submitted (2011).
- Howell, C., Zhao, J., Koelsch, P., and M. Zharnikov, Hybridization in ssDNA films - a multi-technique spectroscopy study, Physical Chemistry Chemical Physics, Webpublished (2011).
- Howell, C., Hamoudi, H., Heissler, S., Koelsch, P., Zharnikov, M., Orientation changes in surface-bound hybridized DNA undergoing preperation for ex situ spectroscopic measurements, Physical Chemistry Letters, Webpublished (2011).
- Konietzny, R., Barth, C., Harms, S., Raetzke, K., Koelsch, P., and C. Staudt, Structural investigations and swelling behavior of 6FDA-copolyimide thin films, Polymer International, Webpublished (2011).
- Schreiner, S. M., Hatch, A. L., Shudy, D. F., Howell, C., Zhao, J., Koelsch, P., Zharnikov, M., Petrovykh, D. Y., and A. Opdahl, Impact of DNA-surface interactions on the stability of DNA hybrids, Analytical Chemistry, 83(11), 4288-4295 (2011).
- Staudacher, I., Wang, L., Wan, X., Obers, S., Wenzel, W., Tristram, F., Koschny, R., Staudacher, K., Bloehs, R., Kisselbach, J., Koelsch, P., Schweizer, P.A., Katus, H.A., Ficker, E., and D. Thomas, hERG K+ channel-assosciated cardiac effects of the antidepressant drug desipramine, Naunyn-Schmiedeberg’s Archives of Pharmacology, 383 (2), 119-139 (2011).
- Düsselberg, D., Verreault, D., Koelsch, P., and C. Staudt, Synthesis and characterization of novel, soluble sulfur containing copolyimides with high refractive indices, Journal of Materials Science, 46, 4872-4879 (2011).
- Diesner, M.-O., Howell, C., Kurz, V., Verreault, D., and P. Koelsch, In vitro characterization of surface properties through living cells, Journal of Physical Chemistry Letters, 1, 2339-2342 (2010).
- Howell, C., Maul, R., Wenzel, W., and P. Koelsch, Interactions of hydrophobic and hydrophilic self-assembled monolayers with water as probed by sum-frequency-generation spectroscopy, Chemical Physics Letters, 494(4-6), 193-197 (2010).
- Verreault, D., Kurz, V., Howell, C., and P. Koelsch, Sample cells for probing solid/liquid interfaces with broadband sum-frequency-generation spectroscopy, Review of Scientific Instruments, 81(6), 063111 (2010).
- Tunc, I., Bruns, M., Gliemann, H., Grunze, M., and P. Koelsch, Bandgap determination and charge separation in Ag@TiO2 core shell nanoparticle films, Surface and Interface Analysis, 42(6-7), 835-841 (2010).
- Kurz, V., Grunze, M., and P. Koelsch, In-situ characterization of thermo-responsive poly(N-isopropylacrylamide) films with sum-frequency generation spectroscopy, ChemPhysChem, 11(7),1425-1429 (2010).
- Motschmann, H., Koelsch, P., Linear and non-linear optical techniques to probe ion profiles at the air-water interface, W. Kunz (Editor) , Specific Ion Effects in Nature and Technology, World Scientific Publishing (2009).
- Ballav, N., Koelsch, P., and M. Zharnikov, Orientation and ordering in monomolecular films of sulfur-modified homo-oligonucleotides on gold, Journal of Physical Chemistry C 113 (42), 18312-18320 (2009).
- Fukunaga, A., Urayama, K., Koelsch, P., and T. Takigawa, Electrically driven director-rotation of swollen nematic elastomers as revealed by polarized Fourier transform infrared spectroscopy, Physical Review E 79, 051702 (2009).
- Jribi, R., E. Barthel, H. Bluhm, M. Grunze, P. Koelsch, D. Verreault, and E. Sondergard, Ultraviolet irradiation suppresses adhesion on TiO2, Journal of Physical Chemistry C 113(19), 8273-8277 (2009).
- Howell, C.L., M. Diesner, M. Grunze, and P. Koelsch, Probing the extracellular matrix with sum-frequency-generation spectroscopy, Langmuir 24(24), 13819-13821 (2008).
- Howell, C., R. Schmidt, V. Kurz, and P. Koelsch, Sum-frequency-generation spectroscopy of DNA films in air and aqueous environments, Biointerphases 3(3), FC47-FC51 (2008).
- Koelsch, P., P. Viswanath, H. Motschmann, V.L. Shapovalov, G. Brezesinski, H. Mohwald, D. Horinek, R.R. Netz, K. Giewekemeyer, T.S. Alditt, H. Schollmeyer, R. von Klitzing, J. Daillant, and P. Guenoun, Specific ion effects in physicochemical and biological systems: Simulations, theory and experiments, Colloids and Surfaces A 303(1-2), 110-136 (2007).
- Aksenov, V., R. Stannarius, M. Tammer, P. Kolsch, F. Kremer, M. Rossle, and R. Zentel, FTIR spectroscopy of smectic elastomer films under lateral strain, Liquid Crystals 34(1), 87-94 (2007).
- Slotta, U., M. Tammer, F. Kremer, P. Koelsch, and T. Scheibel, Structural analysis of spider silk films, Supramolecular Chemistry 18(5), 465-471 (2006).
- Petrov, M., B. Minofar, L. Vrbka, P. Jungwirth, P. Koelsch, and H. Motschmann, Aqueous ionic and complementary zwitterionic soluble surfactants: Molecular dynamics simulations and sum frequency generation spectroscopy of the surfaces, Langmuir 22(6), 2498-2505 (2006).
- Andersen, A., J. Oertegren, P. Koelsch, D. Wantke, and H. Motschmann, Oscillating bubble SHG on surface elastic and surface viscoelastic systems: New insights in the dynamics of adsorption layers., Journal of Physical Chemistry B 110(37), 18466-18472 (2006).
- Schneider, M., A. Andersen, P. Koelsch, and H. Motschmann, Following fast adsorption processes with surface plasmon spectroscopy: reflectivity versus mismatch tracking, Sensors and Actuators B-Chemical 104(2), 276-281 (2005).
- Koelsch, P. and H. Motschmann, Relating foam lamella stability and surface dilational rheology, Langmuir 21(14), 6265-6269 (2005).
- Koelsch, P. and H. Motschmann, Varying the counterions at a charged interface, Langmuir 21(8), 3436-3442 (2005).
- Koelsch, P. and H. Motschmann, An experimental route to Hofmeister, Current Opinion in Colloid & Interface Science 9(1-2), 87-91 (2004).
- Koelsch, P. and H. Motschmann, A method for direct determination of the prevailing counterion distribution at a charged surface, Journal of Physical Chemistry B 108(48), 18659-18664 (2004).
- J. F. Wolf, P. E. Hillner, R. Bilewicz, P. Kölsch, J. P. Rabe, Novel scanning near-field optical microscope (SNOM)/scanning confocal optical microscope based on normal force distance regulation and bent etched fiber tips, Review of Scientific Instruments 70(6), 2751-2757 (1999).
- M. de Ruijter, P. Kölsch, M. Vou, J. De Coninck, J.P. Rabe, Effect of temperature on the dynamic contact angle, Colloids and Surfaces A 144(1-3), 235-243 (1998).
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